IBUB
Institut de Biomedicina de la Universitat de Barcelona
Drug and target discovery for biomedical science
The Institute of Biomedicine of the University of Barcelona (IBUB) is a transversal research unit formed by some 40 groups from the Faculties of Biology, Chemistry and Pharmacy and Food Sciences. The IBUB was created in 2006 with the aim of identifying, beyond the traditional academic structures (departments and faculties), a set of laboratories with complementary scientific activity, capable of generating synergies.
News
1st IBUB Early Career Day
#8M, International Women’s Day
Conference on Rare Diseases Research
Technology Transfer Opportunities
One of the key strengths of IBUB is its ability to successfully transfer knowledge to society
Projects
314
Research groups
40
Publications
725
Research
The need for a wider view on the metabolic syndrome
Marià Alemany, Prof. Emeritus, Fac. Biology, UBDate
April 8, 2024Time
13:00hPlace
Aula Graus, Ed. Durfort, Fac. BiologyOptimizing Molecular Conformations and Interactions for Drug Design
Julian Fuchs, Computational Chemistry at Boehringer IngelheimDate
March 22, 2024Time
13:00hPlace
Aula Magna, Fac. PharmacyNew mitochondrial mechanisms in health and disease
Marc Liesa Roig, IBMB, CSICDate
March 11, 2024Time
13:00hPlace
Aula Graus, Ed. Durfort, Fac. BiologyArticle of the month
Marco Bertolini, Lorena Mendive-Tapia, Ouldouz Ghashghaei, Abigail Reese, Charles Lochenie, Anna M. Schoepf, Miquel Sintes, Karolina Tokarczyk, Zandile Nare, Andrew D. Scott, Stephen R. Knight, Advait R. Aithal, Amit Sachdeva, Rodolfo Lavilla, Marc Vendrell
ACS Central Science
Nonperturbative Fluorogenic Labeling of Immunophilins Enables the Wash-free Detection of Immunosuppressan
Immunosuppressants are clinically approved drugs to treat the potential rejection of transplanted organs and require frequent monitoring due to their narrow therapeutic window. Immunophilins are small proteins that bind immunosuppressants with high affinity, yet there are no examples of fluorogenic immunophilins and their potential application as optical biosensors for immunosuppressive drugs in clinical biosamples. In the present work, we designed novel diazonium BODIPY salts for the site-specific labeling of tyrosine residues in peptides via solid-phase synthesis as well as for late-stage functionalization of whole recombinant proteins. After the optimization of a straightforward one-step labeling procedure for immunophilins PPIA and FKBP12, we demonstrated the application of a fluorogenic analogue of FKBP12 for the selective detection of the immunosuppressant drug tacrolimus, including experiments in urine samples from patients with functioning renal transplants. This chemical methodology opens new avenues to rationally design wash-free immunophilin-based biosensors for rapid therapeutic drug monitoring.
MCP Lab offers a predoctoral contract associated with a project of the AGAUR Program “Indústria del Coneixement”
Data límit
20/1/2024 - Send CV and motivation letterENDED- Call for 6 research initiation grants 2023-2024
Data límit
3 d'octubre 2023. Més informació: https://www.ub.edu/ibub/call-for-6-research-initiation-grants-2023-2024/ Convocatòria: https://seu.ub.edu/ajutsPublic/showPublicacion/441657Facultat de Biologia / Secretaria IBUB & Bioinformàtica
Avda. Diagonal, 643
Edifici Prevosti, planta -1
08028 Barcelona
+34 606 14 87 72
ibub@ub.edu